‘SOMAH’ could buy time for transplant patients.


The 100,000-plus U.S. patients waiting for organ transplants face a perilous race against time. Most organs can only be preserved outside the body for somewhere between four and 24 hours–a problem that aggravates the chronic shortage of donors. In 2008, 6,684 patients died waiting for organs, according to the National Kidney Foundation.

A Harvard scientist is hoping to change those bleak statistics. Hemant Thatte, associate professor of cardiothoracic surgery, has developed a liquid solution that may preserve organs for up to 10 days outside the body. Thatte’s lab at the VA Boston Healthcare System devised a recipe of 21 chemical compounds that they believe will slow down the process of cell deterioration.

In October 2009, Thatte and his colleagues published a paper in the journal Circulation comparing Somah to the widely used preservation solution Celsior, made by biotech company Genzyme. The researchers harvested hearts from female pigs, stored them in one of the two solutions, then biopsied them at several points over the next four hours. They observed the function of the cardiomyocyte and endothelial cells–both of which must be preserved in order for the transplanted heart to survive over the long term. By measuring key proteins, they determined that the rate of cell death was significantly slower in the Somah-preserved hearts than it was in those stored with Celsior. Their experiments in pigs suggest that Somah keeps hearts and livers viable for at least 10 days. By contrast, solutions such as Celsior can only be counted on to preserve hearts and livers for about four and 12 hours, respectively.

Three students who were taking a class at Harvard’s business school got wind of Thatte’s research from Harvard’s Office of Technology Development, and they decided to write up a business plan as an assignment. The team named their startup Hibergenica and set out to find investors in January. They believe they need $5 million to get Somah to market.

The Hibergenica team is pitching investors on the idea that Somah will expand the market for transplanted organs from $30 million a year to as much as $200 million. Some of that growth will arise from an increased supply of viable organs, which could potentially be shipped from faraway places like Hawaii, or even from overseas. Team member Haytham Elhawary, a scientist at Brigham & Women’s hospital who was auditing the business-plan class, believes market expansion might also come from premium pricing–Somah could fetch a price that’s as much as five times higher than competing solutions, he says.

To command that price tag, Hibergenica will have to show that Somah improves the quality of harvested organs, and thus boosts the long-term survival prospects for transplant patients. The solution has the potential to achieve that goal, the entrepreneurs believe, because it is designed to preserve the metabolism of the organs while they are outside the body.

What SOMAH promises


* SOMAH, the new preservative that is a mixture of 21 chemicals, has the potential to store the heart (and other organs) for up to 7 days.

* A research paper published in the medical journal Circulation in October 2009 showed cells of organs preserved in SOMAH had a lower rate of death than in another preservation solution

Organs retrieved from brain-dead persons are stored for a few hours before being transported to various departments or hospitals for transplant. At present, hearts and lungs need to be transplanted within 4-6 hours of being recovered from a brain-dead donor, the liver within eight hours and kidneys within a little more than 24 hours.
What SOMAH—the Sanskrit name for the elixir of immortality—can do is preserve organs long enough to be transported across a large country or half-way across the globe. “Current technologies require that organs from cadaver donors be transplanted within a small window of 4-6 hours. If the transplant surgery cannot take place within that time, the available organ cannot be used. Moreover, the available organs cannot be transported long-distance for transplant and have to be made available locally. The use of SOMAH expands that small window to seven days,” he said.

In technical terms, the preservative slows down the process of cell deterioration.



Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

  • Follow Doctor & Surgeon on WordPress.com
  • Archives

  • Categories

%d bloggers like this: